Amelogenin: extracellular matrix protein for the treatment of hard-to-heal wounds
نویسنده
چکیده
Marco Romanelli is Consultant Dermatologist, Department of Dermatology, University of Pisa, Pisa, Italy Amelogenin is an extracellular matrix protein with biological activity in the regeneration of the periodontium and repair of the skin. Recent published studies have highlighted the use of Xelma® (Mölnlycke Health Care AB, Göteborg, Sweden) in the treatment of hard-to-heal wounds, such as venous leg ulcers. This article reviews the literature relating to the cellular interactions of amelogenin and collates the clinical and health economic data relating to clinical and health economic studies involving patients with chronic wounds. It also discusses a hypothetical mechanism of action of amelogenin in the healing of such wounds.
منابع مشابه
Amelogenin, an extracellular matrix protein, in the treatment of venous leg ulcers and other hard-to-heal wounds: Experimental and clinical evidence
Amelogenins are extracellular matrix proteins that, under physiological conditions, self-assemble into globular aggregates up to micron-sizes. Studies with periodontal fibroblasts indicate that attachment to these structures increases the endogenous secretion of multiple growth factors and cell proliferation. Pre-clinical and clinical studies indicate that cutaneous wounds benefit from treatmen...
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